Possible contribution of cerebellar disinhibition in epilepsy

ObjectiveWe hypothesize that loss of inhibition from the cerebellum can lead to cortical activation and seizures.BackgroundThe traditional model for development seizures purports source is increased electrical activity originating cerebral neurons. Studies have shown a decrease in results shift hyperexcitable state, which may seizures. Interestingly, 1978 study suggested term “disorder disinhibition” as way describe epilepsy studies chronic cerebellar stimulation.Design/methodsCases experimental lesions been implicated were reviewed. Cases has targeted treatment also included. Twenty-six case reports are presented this report.ResultsThe cases show epileptiform activity. Purkinje cell linked occurrence animals. The majority patients with seizure free after complete resection, while less than half partial resection. Novel treatments using deep-brain stimulation targeting structures demonstrated therapeutic benefits seizures.ConclusionsAlthough pathophysiology not well-understood, likely plays an inherent role inhibiting aberrant epileptogenesis. Cerebellar cause due areas or through intrinsic epileptic Treatments enhancing treating seizures, could potentially provide another avenue treatment.